Fig. 1: Comparison of CSP and HBsAg-specific cytokine responses (relative concentrations expressed as ratios of vaccine antigen over background) in antigen stimulated PBMC between R3R (RTS,S-boosted), R3C (RTS,S-unboosted), and C3C (Comparator) vaccine groups.

a Forest plots illustrating fold differences in geometric mean relative concentrations between vaccine groups for all cytokines, one month following the booster at M21 (left) and one year later at M32 (right). Point estimates and whiskers indicate 95% confidence intervals (CI); asterisks (*) indicate significant differences in distributions according to Wilcoxon tests after Benjamini-Hochberg adjustment. b Boxplots showing individual levels and comparing vaccination groups for the five markers that were significantly increased upon vaccination for either CSP- and/or HBsAg-stimulated PBMC samples. The central line in the box represents the median of the relative concentrations in each vaccination group, while the box limits indicate the quartiles.