Fig. 4: Linear epitopes targeted by human IgG and IgM.

A Schematic representation of linear epitope sites on the structural proteins targeted by anti-EV cross-reactive IgM and IgG based on Supplementary Table 1. The epitope names refer to the names assigned in the paper describing them. B Epitope sequences. Note that similar epitopes have been described in multiple papers under different names. For example, the amino-acid sequences of SP70¹⁸³ and VP1-8¹¹⁹ are YPTFGEHKQEKDLEYC and PTFGEHKQEKDLE, respectively. Moreover, several epitopes overlap. For example, E2 (PALTAVET) can be found in the E1 epitope (PALTAVETGATNPL). If the epitope is found within a linear sequence that forms a loop of known importance for viral interactions, the name of the loop is included in parentheses. C, D A three-dimensional image of VP1-4 was generated in ChimeraX using the 6UH1 structure from the protein database¹⁸². Linear epitopes targeted by IgM (C) and IgG (D) are highlighted in pink (VP1), blue (VP4), and yellow (VP2). Image generated using Biorender.