Fig. 10: Recognition patterns of serum IgG antibodies to native and recombinant H. | npj Vaccines

Fig. 10: Recognition patterns of serum IgG antibodies to native and recombinant H.

From: Safety and efficacy of a novel glycoengineered recombinant vaccine candidate against Haemonchus contortus in sheep

Fig. 10

contortus antigens in vaccinated sheep. A vaccination with either Barbervax® (BVAX) or GEA elevated IgG antibodies that bound to soluble proteins of L3 larvae (L3) and adult-stage (Ad) parasites. Parasite-specific IgG appeared earlier in GEA group than in BVAX group. B Cross-reactivities of IgG ware observed in both BVAX- and GEA-antisera; the comparison of Barbervax®-specific IgG (right panel) between the two groups suggested a similar binding pattern and intensity. C Deglycosylation of antigens using sodium metaperiodate (NaIO4) reduced Barbervax®-specific IgG targeting in both groups and completely abolished the recognition of GEA by BVAX IgG.

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