Fig. 5: Changes in fecal microbiota diversity and composition in dogs following immunization and PSC challenge. | npj Vaccines

Fig. 5: Changes in fecal microbiota diversity and composition in dogs following immunization and PSC challenge.

From: Cocktail vaccine induces immunoprotection and modulates the fecal microbiota in dogs against Echinococcus granulosus infection

Fig. 5: Changes in fecal microbiota diversity and composition in dogs following immunization and PSC challenge.

a–f Temporal α-diversity analysis (Shannon and Chao1 indices). In the control group, both indices exhibited a continuous decline, with a significant reduction observed at day 35 (p < 0.05) (a, b). In the rEgFABP1&rEgCaM&rEgSrp1 group, the Shannon index showed a transient increase at day 21, followed by a progressive decline that became significant at day 49 (p < 0.05), whereas the Chao1 index remained unchanged (c, d). In the rEgENO&rEgSev&rEgCyc group, both the Shannon and Chao1 indices increased significantly at day 21 and day 35 (p < 0.05) (e, f). g–i β-diversity analysis based on Bray–Curtis distance. Principal coordinate analysis (PCoA) revealed distinct clustering of fecal microbiota from the control (g), rEgFABP1&rEgCaM&rEgSrp1 (h), and rEgENO&rEgSev&rEgCyc (i) groups. Sample labels: A_a: Group A, Day0; A_b: Group A, Day21; A_c: Group A, Day35; A_d: Group A, Day49. B_a: Group B, Day0; B_b: Group B, Day21; B_c: Group B, Day35; B_d: Group B, Day49. C_a: Group C, Day0; C_b: Group C, Day21; C_c: Group C, Day35; C_d: Group C, Day49.

Back to article page