Table 1 Summary of candidate proteins for vaccination against Echinococcus granulosus in dogs

From: Cocktail vaccine induces immunoprotection and modulates the fecal microbiota in dogs against Echinococcus granulosus infection

Number

Protein

Accession number (UniProtKB)

Antigenicity

Identity rate with Echinococcus multilocularis

Transcriptome Adult PSC

AW ES products

PSC ES products

Cross-species interaction proteins

Associated publications (PubMed ID)

log2(Fold_change)

p value

1

Heat shock 70 kDa protein

A0A068X4W2

0.96

–

–

–

Y

N

Y

23485966;28576342;12911519

2

Calreticulin

W6U953

0.95

96.40%

3.612905779

0.007191408

Y

N

N

17936905; 24013640;17936905

3

Cyclophilina

P14088

0.92

99.40%

–

–

Y

N

Y

12458833; 2677720;12458833;11982600;23012952

4

Fatty acid-binding protein 2

U6JIF2

0.91

96.60%

1.9232459

0.000734653

Y

N

N

24013640; 23485966;32130486;37871121

5

Calmodulina

U6JA54

0.90

97.50%

0.92569322

0.007693969

Y

N

N

24013640; 23485966;29202858;33845889;30846822;25818323

6

Superoxide dismutase

W6V988

0.86

98.70%

–

–

Y

N

Y

24013640;7668094;17432620

7

Severina

U6IX85

0.82

98.60%

–

–

Y

Y

Y

24013640; 23485966;37060967

8

14-3-3 protein

Q56J98

0.76

98.40%

1.141967735

5.21742E-16

Y

Y

Y

24013640; 23485966;22840587

9

Triosephosphate isomerase

U6JN02

0.67

98.80%

–

–

Y

N

Y

24013640; 23485966;30027383;27283960;37871121

10

Fatty acid binding proteina

A0A068WTS7

0.60

–

4.136467735

1.55061E-21

Y

N

N

23485966;26873273;32130486;11731339;12818189;23166848;9169781;9777493;15007640

11

Serine protease inhibitora

U6FVI6

0.59

92.90%

0.825314112

0.003911208

Y

N

N

23485966;19759914;28192542

12

Enolasea

D0VLV3

0.53

98.60%

–

–

Y

N

Y

20127115; 23485966;31508329;22750316;20127115;23373261

13

Annexin

A0A068WJF9

0.50

98.80%

–

–

Y

N

Y

23485966;37803469;33557917;37871121

14

Citrate synthase

U6J0K5

0.43

98.70%

–

–

Y

N

Y

24013640; 23485966;31049696

15

Malate dehydrogenase

A0A068WYB8

0.43

99.70%

–

–

Y

N

Y

23485966;15383291;8352009;8366891

  1. Y yes, include, N no, not include, AW E. granulosus adult worm, PSC E. granulosus protoscolex, ES products excretory/secretory products.
  2. aThe protein names in italics are candidate proteins for vaccination in this study.
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