Fig. 3: Comparison of the strain match between the dominant strain and the WHO vaccine strain, the reproducibly selected strain at WHO timing, and the reproducibly selected strain selected at the delayed timing for the United States of America per season. | npj Vaccines

Fig. 3: Comparison of the strain match between the dominant strain and the WHO vaccine strain, the reproducibly selected strain at WHO timing, and the reproducibly selected strain selected at the delayed timing for the United States of America per season.

From: Reproducible and later vaccine strain selection can improve vaccine match to A/H3N2 seasonal influenza viruses

Fig. 3

A Number of amino acid mutations in epitope sites difference relative to the dominant strain for the vaccine strain and reproducibly selected strains. B Number of amino acid mutations in sites that have resulted in novel antigenic variants difference relative to the dominant strain for the WHO vaccine strain and reproducibly selected strains. C Difference in antigenic distance to the dominant strain between the vaccine strain and the reproducibly selected strains. Pink bars indicate comparison between the dominant strain and the vaccine strain, blue bars indicate comparisons between the dominant strain and the reproducibly selected strain at WHO’s timing, and green bars indicate comparisons at delayed selection timing. Seasons for which comparison via antigenic cartography was not possible because HI tables could not be merged due to inconsistent labeling on antigens between 2004 and 2007 (see “Methods” section), and differences in the use of antivirals between 2010 and 2011 have been indicated with NA.

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