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DISEASE MODELLING

Load-induced osteoarthritis on a chip

Nature Biomedical Engineering volume 3, pages 502–503 (2019)Cite this article

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An osteoarthritis model in a cartilage-on-a-chip, enabled by hyperphysiological compression, recapitulates the progression of the disease and its response to drugs.

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Fig. 1: Induction of an OA phenotype in a cartilage-on-a-chip.

References

  1. Anderson, D. D. et al. J. Orthop. Res. 29, 802–809 (2011).

    Article  Google Scholar 

  2. Wei, F. et al. Osteoarthr. Cartil. 20, 755–763 (2012).

    Article  CAS  Google Scholar 

  3. Verma, P. & Dalal, K. J. Cell. Biochem. 112, 3507–3514 (2011).

    Article  CAS  Google Scholar 

  4. Lin, H., Lozito, T. P., Alexander, P. G., Gottardi, R. & Tuan, R. S. Mol. Pharm. 11, 2203–2212 (2014).

    Article  CAS  Google Scholar 

  5. Johnson, C. I., Argyle, D. J. & Clements, D. N. Vet. J. 209, 40–49 (2016).

    Article  Google Scholar 

  6. Bonnevie, E. D. et al. Cartilage 6, 226–232 (2015).

    Article  Google Scholar 

  7. Mohanraj, B., Meloni, G. R., Mauck, R. L. & Dodge, G. R. Osteoarthr. Cartil. 22, 1282–1290 (2014).

    Article  CAS  Google Scholar 

  8. Occhetta, P. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0406-3 (2019).

  9. Leijten, J. C. H. et al. Arthritis Rheum. 64, 3302–3312 (2012).

    Article  CAS  Google Scholar 

  10. Gardner, O. F. W., Fahy, N., Alini, M. & Stoddart, M. J. J. Tissue Eng. Regen. Med. 11, 2663–2666 (2017).

    Article  CAS  Google Scholar 

  11. Visone, R. et al. Adv. Mater. Technol. 4, 1800319 (2019).

    Article  Google Scholar 

  12. Cope, P. J., Ourradi, K., Li, Y. & Sharif, M. Osteoarthr. Cartil. 27, 230–239 (2019).

    Article  CAS  Google Scholar 

  13. Fabre, K. M., Livingston, C. & Tagle, D. A. Exp. Biol. Med. (Maywood) 239, 1073–1077 (2014).

    Article  CAS  Google Scholar 

  14. Panicker, S., Borgia, J., Fhied, C., Mikecz, K. & Oegema, T. R. Osteoarthr. Cartil. 17, 1014–1021 (2009).

    Article  CAS  Google Scholar 

  15. Berenbaum, F., Griffin, T. M. & Liu-Bryan, R. Arthritis Rheumatol. 69, 9 (2017).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Biomaterials and Bioengineering Laboratory, Division of Pulmonology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Riccardo Gottardi

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  1. Riccardo Gottardi
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Correspondence to Riccardo Gottardi.

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Gottardi, R. Load-induced osteoarthritis on a chip. Nat Biomed Eng 3, 502–503 (2019). https://doi.org/10.1038/s41551-019-0427-y

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