Extended Data Fig. 3: Dual-31/51-20K-mediated mitigation of kidney lesions in MRL/lpr mice. | Nature Biomedical Engineering

Extended Data Fig. 3: Dual-31/51-20K-mediated mitigation of kidney lesions in MRL/lpr mice.

From: Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells

Extended Data Fig. 3

The ability of dual-31/51-20 K to reduce kidney lesions, as reflected by H&E staining of the 0.5 µg treatment groups, with the mononuclear cells infiltrating into the cortical tubulointerstitial/perivascular areas and the scores of glomerular and perivascular lesions shown by arrows and bar graphs, respectively. The data are presented as the mean ± SEM, n = 4 biologically independent mice per group. Statistical analysis was performed using one-way ANOVA (Dunnett’s multiple-comparison test compared with PBS treated group). Representative results from one of two experiments are shown. See also Fig. 5b, c.

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