Extended Data Fig. 2: Validation of Treg-selective activation, as reflected by increased expression of CD25 and FoxP3 by PEGylated IL-2s in a xeno-GvHD mouse model. | Nature Biomedical Engineering

Extended Data Fig. 2: Validation of Treg-selective activation, as reflected by increased expression of CD25 and FoxP3 by PEGylated IL-2s in a xeno-GvHD mouse model.

From: Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells

Extended Data Fig. 2

The MFI bars graphs (top) and flow cytometry histograms (bottom) of induced CD25 and Foxp3 on Tregs and CD8 + T cells in response to IL-2 and its PEGylated variants at a dose of 2 µg, with PBS as the background. The data are presented as the mean ± SEM, n = 3 biologically independent mice per group. Statistical analysis was performed using one-way ANOVA (Dunnett’s multiple-comparison test compared with IL-2 treated group). Representative results from one of three independent experiments are shown. See also Fig. 4a, b.

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