Extended Data Fig. 2: A proposed two-electron reduction process of radiation-induced reduction of the Pt(IV) complex. | Nature Biomedical Engineering

Extended Data Fig. 2: A proposed two-electron reduction process of radiation-induced reduction of the Pt(IV) complex.

From: Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Extended Data Fig. 2

It is initiated by a one-electron reduction of the Pt(IV) complex to give a metastable hexacoordinated Pt(III) intermediate. This is followed by a subsequent acetate ligand detachment with a low activation free energy to form a pentacoordinated Pt(III) species, which is then reduced by the second electron through a barrierless concerted process. Values calculated at the SMD/M06-2X/ aug-cc-pVTZ level of theory.

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