Extended Data Fig. 4: Radiotherapy-induced controlled release of oxaliplatin inhibits the growth of cancer cells. | Nature Biomedical Engineering

Extended Data Fig. 4: Radiotherapy-induced controlled release of oxaliplatin inhibits the growth of cancer cells.

From: Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Extended Data Fig. 4

a, Schematic representation of radiotherapy-induced release of oxaliplatin. b, Cell viability assay of radiation-induced controlled release of oxaliplatin in HCT116, Ls513, LoVo and HT29 cancer cells (n = 6; mean ± s.d., two-tailed unpaired Student’s t-test). Control, without treatment; X-ray, 4 Gy; OxaliPt(IV)-(Suc)2, 10 μM; OxaliPt(IV)-(Suc)2 + X-ray, 10 μM + 4 Gy. c, Pt distribution in different organs in the time span of 48 h after oxaliPt(IV)-(Suc)2 tail vein injection (n = 3, mean ± s.d.).

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