Extended Data Fig. 3: Expression and localization of CMYA5 in hiPSC-CMs and murine cardiomyocytes.
From: Virally delivered CMYA5 enhances the assembly of cardiac dyads
a-c. Expression of Cmya5, Fsd2, and Ryr2 mRNAs during murine heart development. Gene expression was measured in purified ventricular cardiomyocytes at the indicated stage by RNA-seq. Data are from GSE195902. n = 3 per time point. d. Co-localization of miniCMYA5 with ACTN2 in patterned hiPSC-CMs. e. Increased organization of RYR2/jSR induced by miniCMYA5 in hiPSC-CMs was not sufficient to stimulate detectable formation of T-tubules, marked by CAV3. Bar = 5 µm. Data are shown as mean ± SD.
