Extended Data Fig. 1: Schematic of commercial high-throughput sequencing chemistries. | Nature Biomedical Engineering

Extended Data Fig. 1: Schematic of commercial high-throughput sequencing chemistries.

From: A fuzzy sequencer for rapid DNA fragment counting and genotyping

Extended Data Fig. 1: Schematic of commercial high-throughput sequencing chemistries.

(a) Schematic of Cyclic reversible terminator (CRT) used by Illumina and MGI. (b) Schematic of triple-nucleotide addition (TritSeq). (c) Nucleotide substrates used in different sequencing chemistries. The TPLFN is used in fluorogenic sequencing, that is, error-correction code (ECC) sequencing, BitSeq and SuperBitSeq. (d) The information efficiency of different sequencing technologies. Compared with SNA or CRT, BitSeq and SuperBitSeq show higher information efficiency that can be illustrated as the product of intrinsic and extrinsic components.

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