Extended Data Fig. 4: Analysis of editing in extrahepatic tissues liver and toxicity markers after systemic RNA-LNP delivery into macaques.
From: Spatial profiling of gene editing by in situ sequencing in mice and macaques
Quantification of (a) liver toxicity markers and (b) inflammatory biomarkers or cytokines before and during treatment. Bars represent mean ± s.d. Empty datapoints represent animals from strategy 1 and filled datapoints represent animals from strategy 2. Circle and square datapoints represent values of independently treated animals (2 animals per strategy). Vertical dotted lines represent the time point of I.V. infusion. (c-d) Quantification of editing in extrahepatic organs in animals from strategy 1 and 2. Each datapoint represents the values of independently treated animals. A control group was not included due to the unavailability of liver tissue from untreated macaques.
