Extended Data Fig. 6: Comparison of in vivo therapeutic effects of HPL and luminol in ALI mice.
From: Engineering a macromolecular JAK inhibitor for treating acute inflammation and endotoxaemia
a, The lung wet-to-dry weight ratios of mice after treatment with luminol sodium salt and HPL by i.v. injection at 2.9 mg/kg luminol (n = 5 mice). b-f, The mRNA levels of TNF-α (b), IL-1β (c), IL-6 (d), MPO (e), and IL-8 (f) in lung tissues from ALI mice (n = 5 mice). g-k, The protein levels of TNF-α (g), IL-1β (h), IL-6 (i), IL-8 (j), and MPO (k) in BALFs (n = 5 mice). l-m, Flow cytometric profiles (l) and quantitative analysis (m) of neutrophils in BALFs (n = 5 mice). n, Micrographs of H&E-stained lung tissue sections. The results represent biological replicates, with data expressed as mean ± standard error of the mean. P values were determined using one-way ANOVA followed by the LSD test for multiple comparisons.
