Extended Data Fig. 7: Comparison of in vivo therapeutic effects of HPL and typical anti-inflammatory drugs in ALI mice.
From: Engineering a macromolecular JAK inhibitor for treating acute inflammation and endotoxaemia
a, Schematic illustration of treatment regimens. b, The lung wet-to-dry weight ratios of mice after treatment with different formulations (n = 5 mice). c-f, The relative mRNA levels of TNF-α (c), IL-1β (d), IL-6 (e), and IL-8 (f) in lung tissues from ALI mice after treatment with different formulations (n = 6 mice). g-j, Quantified relative mRNA levels of TNF-α (g), IL-1β (h), IL-6 (i), and IL-8 (j) in BALFs (n = 3 mice). k, The mRNA level of MPO in lung tissues (n = 6 mice). l-m, Flow cytometric profiles (l) and quantitative analysis (m) of neutrophils in BALFs of ALI mice (n = 5 mice). n, Micrographs of H&E-stained lung tissue sections. Injured lesions in the lung tissues are indicated by black arrows. The results represent biological replicates, with data expressed as mean ± standard error of the mean. P values were determined using one-way ANOVA followed by the LSD test for multiple comparisons.
