Extended Data Fig. 4: Complex 1 sensitized RT enhances abscopal effect on syngeneic CT26 tumour model.
a, Schemes of primary and secondary tumour inoculation and therapies. b, Primary and secondary tumour growth curves of each mouse showed 1 in combination with RT and αPD-1 suppress growth of bilateral tumours. c, Average primary tumour growth curves of each group (n = 8). d, Average secondary tumour growth curves of each group (n = 8). Tumour growth with the passage of time was compared by two-way ANOVA (Tukey’s test). e, Survival curves showed 1 in combination with RT and αPD-1 prolonged survival time of mice in bilateral tumour model (n = 8). Differences in survival were determined for each group by the Kaplan–Meier method, and the overall P value was calculated by the log-rank test. f, Body weight change curve of mice (n = 8). All the values in the present study are presented as the mean ± s.d., and all replicates are biological independent samples.
