Extended Data Fig. 1: Macrophage infiltration and the expression of MSLN in lung cancer. | Nature Biomedical Engineering

Extended Data Fig. 1: Macrophage infiltration and the expression of MSLN in lung cancer.

From: MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis

Extended Data Fig. 1: Macrophage infiltration and the expression of MSLN in lung cancer.The alternative text for this image may have been generated using AI.

a, Analysis of epithelial and immune cell population in brain metastasis of lung cancer using the single cell sequencing data of URECA (http://ureca-singlecell.kr/). b, Population of different immune cells in brain tumors was analyzed using the PRECOG dataset30. Population analysis of different immune cells in brain tumors [Astrocytoma (n = 341), glioblastoma (n = 697), meningioma (n = 68), and oligodendrogliomas (n = 276)] was performed using the PRECOG dataset30. c, The expression levels of CD14+ monocyte/macrophage and Reg-TAMs markers (CD163, Arg1, Arg2) were investigated in the tumor adjacent normal brain (Non-tumor) and brain metastatic (BM) lesions of lung cancer patients using the TIMER2.0 dataset. Unpaired two-tailed t-test: *, p = 0.04. (n = 5 / group). d, Analysis of mRNA expression of MSLN in different brain regions and in distant organs using Human Protein Atlas data (https://www.proteinatlas.org/). e, Analysis of the expression of MSLN and other lung cancer tumor antigens in the brain metastatic samples using single-cell RNA sequencing. The data are presented as the mean ± SD.

Back to article page