Extended Data Fig. 5: Data analysis of the electrophysiological signals. | Nature Biomedical Engineering

Extended Data Fig. 5: Data analysis of the electrophysiological signals.

From: Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology

Extended Data Fig. 5: Data analysis of the electrophysiological signals.The alt text for this image may have been generated using AI.

a, Overview of 30 example channels of one recording after filtering. Scale bars: 100 ms (horizontal) and 50 μV (vertical). b, 5 times of the rms noise defines the thresholds of the single processing, exceeding which defines a peak. Scale bars: 5 ms (horizontal) and 20 μV (vertical). c, Overview of all the detected peaks of one example channel. Scale bars: 0.5 ms (horizontal) and 20 μV (vertical). d, UMAP visualization of clustered peaks. e, The characteristic waveforms of each cluster in (d), showing different scenarios of neural signals, optical artifacts (from microscope Laser source), and mechanical artifacts. Scale bars: 0.5 ms (horizontal) and 20 μV (vertical). f, Labeling the detected peaks with their cluster information allows to remove artifacts in processed recording data. Scale bars: 100 ms (horizontal) and 20 μV (vertical) for the overview plot, and 10 ms (horizontal) and 20 μV (vertical) for the superimposed zoom-in plot. g, Raster plots of the neural spikes from 240 channels of one recording (hCO, day 88) before and after artifact removing.

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