Extended Data Fig. 3: Partial prediction of cochlear InDel patterns by cell profiles and algorithms. | Nature Biomedical Engineering

Extended Data Fig. 3: Partial prediction of cochlear InDel patterns by cell profiles and algorithms.

From: Template-independent genome editing and restoration for correcting frameshift disorders

Extended Data Fig. 3: Partial prediction of cochlear InDel patterns by cell profiles and algorithms.

a, InDel profiles of 118 deafness mutation-gRNA combinations from mouse cochlea tissue (left) and mouse N2a cells (right), sorted by the Pearson correlation coefficient (R, red square). Read counts for each combination are shown as dark blue side bars. b, InDel profiles predicted by the inDelphi algorithm. Note that inDelphi does not output NT information for changes larger than +1. c, InDel profiles predicted by the FORECasT algorithm. d, Averaged InDel patterns for I-strands and C-strands. e–g, Examples of mirrored patterns between cochlea and N2a cell profiles, with the N2a profiles showing certain large NT number change events.

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