A previously unidentified protein complex termed Shieldin acts with the nucleosome-binding protein 53BP1 to limit end resection at DNA double-strand breaks, impacting myriad biological outcomes, from immunology to cancer therapy, and highlighting the importance of chromatin responses to DNA damage in vertebrates.
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Greenberg, R.A. Assembling a protective shield. Nat Cell Biol 20, 862–863 (2018). https://doi.org/10.1038/s41556-018-0152-x
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DOI: https://doi.org/10.1038/s41556-018-0152-x
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