Supplementary Figure 2: Inter/transgenerational inheritance of stress adaptation is a general feature of mitochondrial dysfunction.
From: N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation
a,b, ATP content of worms in each generation in the intergenerational (a) and transgenerational (b) experiment. c-g, Intergenerational inheritance experiment tested in wild-type animals treated with TTFA (c), sodium azide (d), or 0.32 μM (e) 0.64 μM (f) and 1.28 μM (g) tunicamycin. n = 3 biologically independent experiments (a-g), ~ 10,000 animals per experiment (a,b), >100 animals per experiment (c-g). Data are presented as mean ± s.e.m. Statistical analysis was performed by paired two-tailed t-test; ns, not significant, P > 0.05. P-values are calculated based on comparison between single and sequential exposure groups. Statistical source data are provided in Supplementary Table 7.
