Supplementary Figure 2: TIMER-predicted immune cell infiltration in TCGA (non-TNBC) and METABRIC (TNBC) dataset.

a. Unsupervised hierarchical clustering of TIMER scores of six indicated immune cells in non-TNBC (n=986) of the TCGA dataset after z-transformation. Yellow or blue rectangle indicates potential NES or MES tumours, respectively. TIN: Tumour-infiltrating neutrophils, TIM: Tumour-infiltrating macrophages, DC: Dendritic cells. b. tSNE analyses of the same tumours as examined in (a). Clusters potentially representing “cold”, “MES”, and “NES” subtypes are indicated by grey, blue, and yellow circles, respectively. The colour of each tumour (dot) is determined first by if a tumour is considered “cold” (see Methods), and then by degree of enrichment of TIN or TIM as gauged by the difference of their Z-scores. c. Same as (b), except in TNBC of the METABRIC dataset (n=320).