Extended Data Fig. 2: In-Silico Pan-Tumor Analysis Predicts Synthetic Lethal Partners of ASNS.
From: Translational reprogramming marks adaptation to asparagine restriction in cancer
a, Sensitivity to the PLK1/3 inhibitor GW843682X of pan-tumor cell lines segregated based on high (ASNShi) and low (ASNSlo) ASNS expression. P-value calculated by one-sided Wilcoxon rank sum test. Each dot represents a cell line (ASNShi, n=204; ASNSlo, n=20). Middle line and the whiskers represent the mean and the standard deviation respectively. b, Conditional essentiality of PLK1 (ASNShi, n=24; ASNSlo, n=22), JAK3 (ASNShi, n=69; ASNSlo, n=67) and ATF4 (ASNShi, n=69; ASNSlo, n=67) in ASNSlo and ASNShi cell lines. One-sided Wilcoxon rank sum P values are denoted for each gene knockdown. Data information: In the boxplots, the top and bottom horizontal lines represent the 75th and the 25th percentile, respectively, and the middle horizontal line represents the median. The size of the box represents the interquartile range, and the top and bottom whiskers represent the maximum and the minimum values respectively.
