Extended Data Fig. 2: Bcat2 knockout impedes PDAC development at early stage.
From: BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma
a, b, Bcat1 has no functional compensation in KC;Bcat2-/- mice (n = 6 biologically independent animals). Representative images of Bcat1(a) and Bcat2 (b) staining. c-g, Representative images of staining with alcian blue (c), sirius red (d), and a serial section of Bcat2 (e), Ki67 (f) and CK19 (g) of pancreatic tissues from KC, KC;Bcat2+/- or KC; Bcat2-/- mice (6 months, n = 6 biologically independent animals, pancreatic acinar and duct indicated as arrow or asterisk, respectively, scale bar: c,d: 50 μm; a,b,e,f,g: 12.5 μm).
