Extended Data Fig. 9: PLCγ1 deletion accelerates lung tumorigenesis in mice. | Nature Cell Biology

Extended Data Fig. 9: PLCγ1 deletion accelerates lung tumorigenesis in mice.

From: PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Extended Data Fig. 9

a, Representative hematoxylin & eosin (H&E) staining of LSL-KrasG12D/WT;p53flox/flox;Plcg1wt/wt, LSL-KrasG12D/WT;p53flox/flox;Plcg1wt/flox and LSL-KrasG12D/WT;p53flox/flox;Plcg1flox/flox mouse lung sections, 10 weeks after Cre induction. Scale bar: 5000μm. b, Representative immunohistochemistry images showing Ki67-positive cell staining in mouse lung tumors from LSL-KrasG12D/WT;p53flox/flox;Plcg1wt/wt, KrasG12D/WT;p53flox/flox;Plcg1wt/flox and LSL-KrasG12D/WT;p53flox/flox;Plcg1flox/flox mice 10 weeks after Cre induction. This is related to main Fig. 7e.

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