Extended Data Fig. 1: scRNA-seq profiling of the cervix.
From: Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia
a, UMAP of single cell transcriptomes obtained from healthy mouse endocervix, ectocervix and TZ as in Fig. 1b. Here, cells are labelled by the tissue of origin. b, Normalized expression of selected markers (Sfn, Epcam, Acta2, Col6a2, Cd52, Pcam1, Rgs5 and S100b) colour-coded on the UMAP, representing cellular sub-clusters. c, UMAP of epithelial sub-clusters colour-coded by the tissue of origin. d-h, Normalized expression values of selected markers colour coded on the UMAP representing key epithelial sub-clusters as in Fig. 1d. Color maps of squamous type (Sq_1): Birc5, Mki67, Cks2, Hmgb2; Sq_2A and Sq_2B: Trp63, Krt5, Dkk3, Notch1; Sq_3: Fam25c, Gm94, Krt6, Krt10; Columnar type (Co_1): Anpep, Cxcl17, Krt8, Krt18; Co_2: Krt19, Ltf, Muc1, Psca; n = 3 biologically independent mice experiments.
