Extended Data Fig. 7: Anorexia-associated body mass changes of human pancreatic cancer implanted mice. | Nature Cell Biology

Extended Data Fig. 7: Anorexia-associated body mass changes of human pancreatic cancer implanted mice.

From: Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain

Extended Data Fig. 7: Anorexia-associated body mass changes of human pancreatic cancer implanted mice.The alternative text for this image may have been generated using AI.

a, Tumor volumes were increased in Panc1 and Capan1 implanted mice. n = 4 mice for three groups; 3 week *P = 0.049, 4 week *P = 0.049, 5 week *P = 0.033. b, Body mass were reduced in Panc1 and Capan1 implanted mice compared to the control mice. n = 4 mice for each group; 3 week Panc1 **P = 0.0014 and Capan1 *P = 0.049, 5 week Panc1 ***P < 0.0001 and Capan1 ***P < 0.0001. 6 week Panc1 ***P < 0.0001 and Capan1 ***P < 0.0001. c, Relaxin-INSL family mRNA expression levels in Capan1 cells. n = 3 biologically independent experiments; Rxn vs INSL3 **P = 0.003. Data are presented as the mean ± s.e.m. Statistical significance was determined with two-tailed Student’s t-test; *P < 0.05. Statistical source data.

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