Extended Data Fig. 4: Lis1 does not affect stall time and stepping rate of single dynein bound to dynactin.
From: Lis1 activates dynein motility by modulating its pairing with dynactin
a, Distribution of dwell times between consecutive steps along the longitudinal axis of the MT. A fit to an exponential decay reveals the decay rate (rate ± SE, n = 734 for mtDTR-Lis1 and 724 for mtDTR+Lis1). b, Inverse cumulative distribution of stall durations of mtDTR in the presence and absence of 600 nM Lis1. Solid curves represent fitting to a two-exponential decay (decay time ± SE, n = 118 for mtDTR-Lis1 and 100 for mtDTR+Lis1, three independent experiments).Â
