Extended Data Fig. 3: Lis1 does not increase the stall duration of dynein bound to dynactin and a cargo adaptor.
From: Lis1 activates dynein motility by modulating its pairing with dynactin
a, Inverse cumulative distribution of stall durations in the absence and presence of 600 nM Lis1. Solid curves represent fitting to a two-exponential decay (decay time ± SE). b, Mean stall times of mtDDB and mtDDR in absence and presence of 600 nM Lis1 (± SEM). p values are calculated from a two-tailed t-test. In a and b, n = 53, 27, 50, and 39 from left to right, four independent experiments per condition.Â
