Extended Data Fig. 6: Construction of Nlrp3Y30E/Y30E mice.
From: Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
a, Nlrp3Y30E/Y30E mice was generated using CRISPR/Cas9-mediated genome editing. The sequence of guide RNA (gRNA) binding site on the homologous DNA sequence had indicated. b, Nlrp3Y30E/Y30E mice was validated by DNA sequencing.
