Extended Data Fig. 8: Myeloid PTEN correlates chemotherapy-induced antitumor immunity in human cancer patients.
From: Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
a, Kaplan–Meier curve analysis of the overall survival probabilities of patients with breast cancer influenced by PTEN expression. Ptenlow groups n = 177 biologically independent patients, Ptenhigh groups n = 449 biologically independent patients. b-d, Correlations analysis between the MOD of PTEN in tumor cells with IL-1β concentrations in serum (b), CD8α (c) or IFNG (d) mRNA expression in tumor tissues from cohort 1. n = 32 biologically independent patients. e, Correlations analysis between the MOD of PTEN in tumor cells and IL-1β concentrations in serum from cohort 2. n = 34 biologically independent patients. Statistics were analyzed using two-sided log-rank (Mantel–Cox) test (a) or two-sided unpaired Student’s t-test (b-e). Source data are provided in Source Data Extended Data Fig. 8.
