Extended Data Fig. 10: Schematic describing emergence of a novel transitional cell state in alveolar stem cell-mediated epithelial regeneration and its persistence in disease pathogenesis. | Nature Cell Biology

Extended Data Fig. 10: Schematic describing emergence of a novel transitional cell state in alveolar stem cell-mediated epithelial regeneration and its persistence in disease pathogenesis.

From: Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

Extended Data Fig. 10

Alveolar stem cells replicate in response to damage and generate a novel transitional cell state which normally matures into functional alveolar type-1 epithelial cells. The previously unappreciated transitional state is directly regulated by TP53 signalling, vulnerable to DNA damage and undergoes a transient senescent state. This state is enriched in human fibrotic lungs.

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