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IMMUNOLOGY

The hidden side of PD-L1

Nature Cell Biology volume 22, pages 1031–1032 (2020)Cite this article

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PD-L1 has been extensively described as the membrane-bound ligand of PD-1. A recent study discovered a previously unknown role for PD-L1, which is able to bind DNA and thus govern different pathways linked to either evasion of immune surveillance or tumour microenvironment inflammation.

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Fig. 1: De-acetylation-dependent PD-L1 nuclear translocation supports tumour immune evasion.

References

  1. Baumeister, S. H., Freeman, G. J., Dranoff, G. & Sharpe, A. H. Annu. Rev. Immunol. 34, 539–573 (2016).

    Article  CAS  Google Scholar 

  2. Li, X. et al. Nat. Rev. Clin. Oncol. 16, 425–441 (2019).

    Article  CAS  Google Scholar 

  3. Galluzzi, L., Chan, T. A., Kroemer, G., Wolchok, J. D. & López-Soto, A. Sci. Transl. Med. Rev. 10, eaat7807 (2018).

    Article  Google Scholar 

  4. Azuma, T. et al. Blood 111, 3635–3643 (2008).

    Article  CAS  Google Scholar 

  5. Chang, C. H. et al. Cell 162, 1229–1241 (2015).

    Article  CAS  Google Scholar 

  6. Chen, N. et al. J. Thorac. Oncol. 10, 910–923 (2015).

    Article  CAS  Google Scholar 

  7. Tu, X. et al. Mol. Cell 74, 1215–1226.e4 (2019).

    Article  CAS  Google Scholar 

  8. Song, H. et al. Biochem. Biophys. Res. Commun. 404, 68–73 (2011).

    Article  CAS  Google Scholar 

  9. Gao, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-0562-4 (2020).

  10. Yoo, C. B. & Jones, P. A. Nat. Rev. Drug Discov. 5, 37–50 (2006).

    Article  CAS  Google Scholar 

  11. von Burstin, J. et al. Gastroenterology 137, 361–371 (2009).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland

    Alison Jaccard & Ping-Chih Ho

  2. Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland

    Alison Jaccard & Ping-Chih Ho

Authors
  1. Alison Jaccard
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  2. Ping-Chih Ho
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Correspondence to Alison Jaccard or Ping-Chih Ho.

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The authors declare no competing interests.

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Jaccard, A., Ho, PC. The hidden side of PD-L1. Nat Cell Biol 22, 1031–1032 (2020). https://doi.org/10.1038/s41556-020-0568-y

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