Extended Data Fig. 7: Extended cluster specific analysis. | Nature Cell Biology

Extended Data Fig. 7: Extended cluster specific analysis.

From: Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements

Extended Data Fig. 7

a, Gene Ontology analysis for statistical overrepresentation of biological processes for srHC genes uniquely repressed by each cluster; non-redundant GO categories shown (p-value calculated by PANTHER Statistical overrepresentation test, denoted in panel). N numbers represent number of genes in GO category repressed by srHC protein member of indicated cluster and are stated in panel. b, Profiles of A/B compartment enrichment43, H4K20me1 and DNA methylation by bisulfide sequencing across genes uniquely regulate by each cluster. c, TargetScan database analysis for enrichment of miRNA target sequences in srHC genes uniquely repressed by each cluster; -log2(p-value) shown for the top 55 enriched miRNA target sequences per cluster (p-value calculated using the statistical model developed in Agarwal et al., 2017). d, Heatmap of H3K9me3, H3K27me3 and srHC-seq profiles of srHC genes uniquely regulated by each srHC protein cluster and sorted by mean H3K9me3 level within each cluster set. N numbers represent number of srHC gene profiles depicted and are stated in the panel.

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