Extended Data Fig. 8: srHC protein ChIP-seq. | Nature Cell Biology

Extended Data Fig. 8: srHC protein ChIP-seq.

From: Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements

Extended Data Fig. 8

a, ChIP-seq profiles of HMGA1 and MYBBP1A at srHC genes repressed by both factors or repressed by the other factor. b, Browser track showing ERH at a H3K9me3 marked euchromatin domain. c, srHC and euchromatin H3K9m3 gene expression changes in siERH+hiHep. N numbers represent the number of srHC or euchromatin srHC genes and are stated in the panel. The number of genes in each set significantly up (red) or down (blue) are indicated. d, DNA fragment size profiles by BioAnalyzer of INPUT and eluted DNA after ChIP of the indicated srHC protein. e, Table showing the percent of DNA fragments with length>=1kb as determined by paired-end sequencing for reads mapping with over 50% overlap with euchromatin or srHC domains (two tailed Student’s t-test, n=3 biological replicates sequenced as INPUT).

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