Extended Data Fig. 3: Lineage plastic NE-like tumours exhibit a unique chromatin accessibility profile.
From: An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer
(a) Heatmap of ATAC-seq signal intensity in a GEMM of prostate adenocarcinoma (SKO, Ptenf/f) evolution to a plastic, NE-like state (DKO, Ptenf/f/Rb1f/f; TKO, Ptenf/f/Rb1f/f/Tp53f/f). Each horizontal line represents a 6-kb locus. (b) Motif analysis surrounding ATAC-seq peaks (250-bp) in NE-like DKO and TKO GEMMs compared to SKO. Transcription factor motifs identified by HOMER were plotted by ranks generated from their associated differential p values. (c) Significantly enriched pathways (gene set enrichment analysis) in accessible chromatin regions specific to NE-like DKO and TKO GEMMs compared to SKO.
