Extended Data Fig. 7: EPX potentiates the interaction between EETs and PNECs.
From: Eosinophil extracellular traps drive asthma progression through neuro-immune signals
a-c, Wild-type, EPX−/− and MBP−/− mice were sensitized and challenged with PBS or OVA. a, Quantification of Fig. 7d. b, Levels of indicated type 2 cytokines in BALF were evaluated by ELISA. c, The relative expression levels of CGRP in lung homogenates were examined by qRT-PCR. d, The area (%) of ECP+ SYTOX Green+ and EPX+ SYTOX Green+ signals in BALF smears as shown in Fig. 7f. e-f, PAD4−/− mice were adoptively transferred with eosinophils isolated from wild-type mice or EPX−/− mice. e, Percentages of PAS-stained cells in total epithelial cells in lung sections. f. The inflammatory score quantified from the H&E staining of lung sections. a-f, Mean ± s.d.; n = 6 (e, f) or 10 (a-d) mice per group, representative of two independent experiments; compared by one-way ANOVA with Tukey’s multiple comparisons test.
