Extended Data Fig. 9: RNA-seq data from wild-type, Daxx single KO, Daxx Pu.1 double KO and Pu.1 single KO KLS and GMP cells collected at 3 w.p.i. | Nature Cell Biology

Extended Data Fig. 9: RNA-seq data from wild-type, Daxx single KO, Daxx Pu.1 double KO and Pu.1 single KO KLS and GMP cells collected at 3 w.p.i.

From: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Extended Data Fig. 9: RNA-seq data from wild-type, Daxx single KO, Daxx Pu.1 double KO and Pu.1 single KO KLS and GMP cells collected at 3 w.p.i.The alternative text for this image may have been generated using AI.

a, Venn diagrams of differentially upregulated and downregulated genes in comparison to wild-type KLS. b, Venn diagrams of differentially upregulated and downregulated genes in comparison to wild-type GMP cells. c, IPA graphical summary for KLS Daxx Pu.1 double knock-out specific and Pu.1 single KO specific gene expression changes. d, IPA graphical summary for GMP Daxx Pu.1 double knock-out specific and Pu.1 single KO specific gene expression changes. e, Heatmap showing scaled expression of selected transcription factors and regulators involved in blood cell differentiation (n = 2 mice per genotype). f, Heatmap showing scaled expression of transcription factors regulated by Pu.1 (n = 2 mice per genotype). g, Heatmap showing scaled expression of interferon response genes and the dsRNA recognition machinery (n = 2 mice per genotype). Numerical source data provided in Source data.

Source data

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