Extended Data Fig. 6: IGV showing LLPS enhanced chromatin occupancy at multiple HSP gene loci. | Nature Cell Biology

Extended Data Fig. 6: IGV showing LLPS enhanced chromatin occupancy at multiple HSP gene loci.

From: Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock

Extended Data Fig. 6

(a-f) Integrative genomics viewer (IGV) snapshots for the indicated Cut&Tag signal at the well-known HSP gene foci such as the HSP90AA1 (a), HSP90AB1 (b), HSPA6 (c), HSPB1 (d), HSPH1 (e), and IER5 (f). Samples from top to bottom are HSF1 WT (tracks 1-3), HSF1-M1 (tracks 4-5), HSF1-M3 (tracks 6-7), RNA pol II (tracks 8-9), BRD4 (tracks 10-11), and CYCT1 (tracks 12-13). Tracks 3 and 5 were treated with 1.5% 1,6-hexanediol for 30 mins before Cut&Tag was performed.

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