Extended Data Fig. 9: Enhanced multiplex activation by hyperdCas12a.
From: Multiplexed genome regulation in vivo with hyper-efficient Cas12a
Multiplex endogenous gene activation by hyperdCas12a versus enAsdCas12a and 6-crRNA array targeting Oct4, Sox2 and Klf4 (OSK) in mouse P19 cells as measured by qPCR, in similar experiment as described in Fig. 3a. Each data point shows one independent measurement, and each bar shows the average of n = 3 independent experiments. DR, direct repeat; NT, non-targeting.
