Extended Data Fig. 5: EED-KO and KMT2D-KO generate distinct mesenchymal cell states. | Nature Cell Biology

Extended Data Fig. 5: EED-KO and KMT2D-KO generate distinct mesenchymal cell states.

From: Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

Extended Data Fig. 5

a, UMAP plots showing expression levels of epithelial marker genes CDH1, EPCAM, DSP and mesenchymal marker genes ZEB1, ZEB2 and TWIST1 in C1-sgControl, C1-sgEED and C1-sgKMT2D cells. b, Immunoblot of EMT-TFs SNAIL, ZEB1, EMT markers E-cadherin, pan-cytokeratines and EED, KMT2D in SUM149D2-sgControl, SUM149D2-sgEED-Mes and SUM149D2-sgKMT2D-Mes cells. n = 2 biologically independent experiments.

Source data

Back to article page