Extended Data Fig. 3: Littermate analysis showing that weakened centromeres persist in the male but not female germline.
From: Epigenetic, genetic and maternal effects enable stable centromere inheritance
a, Data from Fig. 1c replotted as CENP-A levels per animal, averaged over all centromeres in each animal and normalized to controls (dashed line). N = 10,10,10, 9, 7 animals. The F1 male but not the female germline and the male and female soma are significantly lower than the controls **P < 0.001, *P < 0.05 n.s.: P > 0.05, Wilcoxon signed sum rank test (two-tailed). b, CENP-A quantifications in spermatocytes and oocytes from littermates from one set of parents. N = 121, 431, 60, 259, 246, 105 centromeres (top to bottom). Female germline levels are significantly elevated compared to littermate male germline levels. **P < 0.0001, Mann–Whitney U Test (two-tailed). Error bars: median ± 95% CI. Source numerical data are available in source data.
