Fig. 1: Transcriptome-wide analysis reveals widespread 3′ UTR splicing.
From: Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
a, Schematic for the identification of 3USPs. b, Venn diagram showing the overlap between 3USPs and c3USPs (in brackets) identified in TCGA-normal, TCGA-tumour and GTEx datasets. c, Bar plots showing the number of 3USPs and c3USPs detected in different numbers of TCGA cancer types. d, Heat map illustrating the percentages of 3USPs and c3USPs supported by PacBio data. e, Distribution of the distance from the stop codon for multiple groups of 3USPs classified by SPLs in TCGA-tumour. f, Cumulative distribution of SPLs of c3USPs in TCGA-tumour with or without Alu elements. P values: Wilcoxon test. g, Bar plots showing the number of significantly upregulated and downregulated c3USPs. h, Heat map illustrating percentages of the identified c3USPs overlapped across ten TCGA cancer types and AML. i, Bar plots showing the number of favourable (hazard ratio <1, P < 0.05) and unfavourable (hazard ratio >1, P < 0.05) c3USPs across ten cancers. Hazard ratios and P values: univariate Cox proportional hazards regression analysis.
