Extended Data Fig. 7: 3’UTR splicing of CTNNB1 promotes HCC tumorigenesis.
From: Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
a-d, Effect of siRNA-mediated knockdown of CTNNB1 CDS, 3’FL and 3’SP on CTNNB1 transcript expression by qPCR (n = 3 independent experiments) (a) and PCR (b), protein expression (c) and anchorage-independent growth (n = 3 independent experiments) (d). siNC: siRNA non-targeting control; CDS: coding sequence; 3’FL: full length 3’UTR; 3’SP: spliced 3’UTR. a,d, Mean ± SEM; unpaired Student’s t-test *p < 0.05, **p < 0.01, ***p < 0.001. b,c, Data shown represent three independent experiments.
