Fig. 2: Pan-cancer analysis identifies CTNNB1 as the top dysregulated c3USP across 11 cancers.
From: Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
a, Box plot illustrating the definition of over- and under-splicing for each significantly dysregulated c3USP event in each cancer type. Each dot represents one sample. The dashed lines indicate the 10% and 90% quantile of SPLs in the normal samples. b, The top ten 3USPs detected in the highest number of total tumour samples across 11 cancers. #, total number of over-spliced tumour samples; %, percentages in the colour key. c, Sashimi plot illustrating 3′ UTR splicing of the top dysregulated splicing event of CTNNB1 in the normal and tumour samples from COAD. d, Number of tumour samples with over- and under-spliced 3′ UTRs for genes with c3USP.
