Extended Data Fig. 1: Global analysis of 3’UTR splicing events with TCGA and GTEx datasets.
From: Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
a, Heatmap illustrating the percentage overlap of c3USPs identified from TCGA-normal and GTEx samples. The rows and columns indicate the TCGA-normal and GTEx tissues, respectively. b, Boxplot showing the distribution of the percentage of 3’UTR splicing events identified in TCGA-normal that overlapped with those from GTEx, including 3USPs, c3USPs and their corresponding backgrounds. c-d, Bar plots showing the number of 3USPs and c3USPs detected in the TCGA-normal samples of different numbers of cancer types (c) and different tissues from GTEx (d). The x-axis indicate the number of cancer types (Supplementary Table 1). e, Proportion of novel c3USPs that are not annotated or reported in previous studies. f-j, Distribution of the distance from the stop codon for multiple groups of c3USPs (f-h) and 3USPs (i,j) classified by splicing levels in TCGA-tumor (f), TCGA-normal (g,i) and GTEx (h,j). k-l, Cumulative distribution of splicing levels of c3USPs in TCGA-normal (k) and GTEx (l) with or without Alu elements. P-values: Wilcoxon test.
