Extended Data Fig. 10: Schematic illustrating the proposed microenvironment alterations for ectopic peritoneal and ovary lesions. | Nature Cell Biology

Extended Data Fig. 10: Schematic illustrating the proposed microenvironment alterations for ectopic peritoneal and ovary lesions.

From: Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues

Extended Data Fig. 10

In peritoneal lesion (left), the proportion of myeloid and endothelial is increased, and endometrial-like epithelial population is reduced. CCL19-expressing perivascular cells mediate immune cell recruitment, such as macrophages and T cells, which contributes to the immunomodulatory microenvironment. We observe the presence of MSR1-expressing dendritic cells contributing to immunomodulation. TLS is also observed in some lesions. In addition, Mø1-LYVE1 and perivascular cells contribute to angiogenesis by regulating endothelial tip proliferation. In contrast, ovarian ectopic lesions (right) show a striking increase in the proportion of stromal cell and a reduced endometrial-like-epithelial cell presence. The immunomodulatory microenvironment is mainly driven by Mø1-LYVE1 expressing IL10. In ovary lesions, the regulation of angiogenesis is marked by endothelial cell arrest, resulting in mature vasculature. Created with Biorender.com.

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