Extended Data Fig. 5: Migrasome delivery promotes EC proliferation and sprouting.
From: Monocytes deposit migrasomes to promote embryonic angiogenesis
(a) Dissected CAMs from E8d were mounted on the top of a collagen I-Matrigel matrix mix, and soft agarose with migrasomes (+Mig) or without migrasomes (-Mig) was added on opposite sides of the CAM. 2, 4 and 6 days after mounting, the samples were visualized by confocal microscopy. Scale bar, 200 µm. (b) The proliferation of ECs and sprouting progression from (a) was quantified by the tube length from the edge of CAM to the angiogenic front. Data are presented as mean ± SEM; n =30 fields of CAM leaflets from five independent experiments; P values were calculated using a two-way ANOVA unpaired multiple comparisons, N.S: no significance (P=0.9681); P < 0.0001. Source numerical data are available in source data.
