Extended Data Fig 5: Details of allele-specific RNA-seq. | Nature Cell Biology

Extended Data Fig 5: Details of allele-specific RNA-seq.

From: Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages

Extended Data Fig 5: Details of allele-specific RNA-seq.The alternative text for this image may have been generated using AI.

(Right) Schematic of B6-ChrXTMSM chromosome used in this study. Telomeric half of the B6 X chromosome is replaced with MSM/Ms X chromosome. (Left) Allele-specific expression ratio in 3 independent EPCs of Ring1A/B control, ∆Ring1A/B, Eed control and ∆Eed E7.5 embryos are represented as heat maps. Maternal expression in red and paternal expression in blue. Total 136 informative genes (122 for Ring1A/B and 132 for Eed) including 5 constitutive escapees (magenta), Xist (Blue), significant escapees upon PRC1 deletion (green), significant escapees upon PRC2 deletion (orange), not informative genes (gray) and silenced genes even in the absence of PRC1 or PRC2 (black) are shown. Values are allele-specific expression ratios in each EPC.

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